Agomelatine is a potent MT1 and MT2 melatonin receptor agonist and a 5-HT2C serotonin receptor antagonist and also has anticonvulsant property .We analyzed whether agomelatine has the potential to inhibit or attenuate ethanol withdrawal induced handling convulsion in mice or not .The anticonvulsant activity of agomelatine (75 mg/kg, i.p.) was evaluated in mouse models of pentylenetetrazole .In the PTZ-induced seizure model, agomelatine treatment was given where acute treatment showed protection against convulsion while chronic agomelatine treatment showed complete absence of convulsions.
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